Acetylsalicylsyre

Teknik A Acetylsalicylsyre Afleveringsdato: Den 27. februar 2008 x

Den 27. februar 2008

Teknik A

Proces, levnedsmidler & sundhed

Tema om medicinfremstilling og

Acetylsalicylsyre

HTX Sukkertoppen Vejleder: x Forsøgene er udført i samarbejde med x

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Teknik A Acetylsalicylsyre Afleveringsdato: Den 27. februar 2008

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Indholdsfortegnelse

Bilagsoversigt .............................................................................................................................................. 4 Forord ......................................................................................................................................................... 5 Indledning ................................................................................................................................................... 6 1) Overordnet formål .................................................................................................................................. 7 2) Teori ........................................................................................................................................................ 8 2.1) Salicylsyre og acetylsalicylsyre........................................................................................................... 8 2.2) Historisk set ...................................................................................................................................... 9 2.3) Industriel fremstilling .......................................................................................................................10 2.3.1) Fremstilling af eddikesyreanhydrid ............................................................................................10 2.3.2) Fremstilling af salicylsyre ...........................................................................................................10 2.3.3) Fremstilling af ASA ....................................................................................................................11 2.4) Økonomisk set .................................................................................................................................11 2.5) Virkninger af acetylsalicylsyre ..........................................................................................................11 2.5.1) Mekanismen bag den smertedæmpende egenskab ...................................................................12 2.5.2) Salicylsyreforgiftning .................................................................................................................13 F R ASA .........................................................................................................14 3.1) Formål .............................................................................................................................................14 3.2) Kort teoretisk baggrund ...................................................................................................................14 3.3) Fremgangsmåde ..............................................................................................................................14 3.3.1) Udstyr .......................................................................................................................................14 3.3.2) Metode .....................................................................................................................................14 3.4) Plan..................................................................................................................................................15 3.5) Resultater & resultatbehandling.......................................................................................................15 3.6) Diskussion & fejlkilder ......................................................................................................................16 F S ASA .....................................................................................................................17 4.1) Formål .............................................................................................................................................17 4.2) Kort teoretisk baggrund ...................................................................................................................17 4.3) Fremgangsmåde ..............................................................................................................................19 4.3.1) Udstyr og kemikalier..................................................................................................................19 4.3.2) Metode .....................................................................................................................................19 4.4) Plan..................................................................................................................................................21

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Teknik A Acetylsalicylsyre Afleveringsdato: Den 27. februar 2008

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4.5) Resultater & resultatbehandling.......................................................................................................22 4.6) Diskussion & fejlkilder ......................................................................................................................22 5) Analyser og tests af det fremstillede ASA ..............................................................................................23 5.1) Overordnet formål ...........................................................................................................................23 5.1) Smeltepunktsbestemmelse ..............................................................................................................23 5.1.1) Formål.......................................................................................................................................23 5.1.2) Fremgangsmåde ........................................................................................................................23 5.1.3) Resultater & resultatbehandling ................................................................................................24 5.2) Bruseeffekt ......................................................................................................................................24 5.2.1) Formål.......................................................................................................................................24 5.2.2) Fremgangsmåde........................................................................................................................24 5.2.3) Resultater & diskussion .............................................................................................................24 5.3) Tyndtlagschromatografisk analyse ...................................................................................................25 5.3.1) Formål.......................................................................................................................................25 5.3.2) Kort teoretisk baggrund om metoden........................................................................................25 5.3.3) Fremgangsmåde ........................................................................................................................26 5.3.4) Resultater og diskussion ............................................................................................................27 5.4) Reaktionsproduktets indhold af ASA ................................................................................................27 5.4.1) Formål.......................................................................................................................................27 5.4.2) Kort teoretisk baggrund.............................................................................................................27 5.4.3) Fremgangsmåde ........................................................................................................................28 5.4.4) Resultater og diskussion ............................................................................................................28 5.5) Spektrofometri.................................................................................................................................29 5.5.1) Formål.......................................................................................................................................29 5.5.2) Kort teoretisk baggrund.............................................................................................................29 5.5.3) Fremgangsmåde standardkurve for salicylsyre........................................................................30 5.5.4) Resultater og diskussion ............................................................................................................32 6) Konklusion .............................................................................................................................................34 Kildeoversigt ..............................................................................................................................................37 Bilag ...........................................................................................................................................................38